Polycystic Ovarian Syndrome
(ND014)
Introduction
Polycystic ovary syndrome
(PCOS) also known as Stein-Leventhal syndrome or functional ovarian hyperandrogenism,
is a complex endocrine disorder associated with a long-term lack of ovulation
(anovulation) and an excess of androgens (male sex hormones, e.g., testosterone)
circulating in the blood. The disorder is characterized by the formation
of cysts in the ovaries, a process related to the failure of the ovary
to release an egg (ovum). In the majority of cases, the ovaries become
enlarged. PCOS afflicts up to 22% of women during their childbearing years, although
only 10% of these women develop symptoms. It is one of the most frequent
causes of infertility in women. Many women with PCOS have the onset of symptoms during adolescence, and
polycystic ovaries may be found by ultrasound even before the onset of
puberty. Ovaries classified as polycystic have eight or more follicular
cysts, 10 mm or less in size. Decisions regarding treatment of PCOS depend on the extent of medical problems
(morbidity) caused by the condition and the woman's preferences regarding
fertility. First line management includes diet modification, weight loss and stress
reduction since obesity and stress alone can contribute to androgen excess.
Other management is directed at the specific symptoms and complications
as follows: Get the Facts... With
your MediFocus Guide
The Medifocus Guide on
Polycystic Ovary Syndrome (POS) provides answers to the following important
questions and medical issues:
- What are the most common symptoms
of POS?
- Are there any recognized risk factors
for developing POS?
- What kinds of medical tests are
used to establish the diagnosis of POS?
- What is the current standard of
care for the treatment of POS?
- What treatment options are available
for the management of POS?
- Are there any promising new developments
or potential breakthroughs in treatment?
- Who are the most notable medical
authorities who specialize in POS?
- Where are the leading hospitals
and centers of research for POS?
- What are the most important questions
to ask my doctor about POS?
What Your Doctor Reads:
This MediFocus Guide contains an extensive listing of citations and abstracts of recent journal
articles that have been published about this condition in trustworthy medical
journals. This is the same type of information that is available to physicians
and other health care professionals. A partial selection of journal articles
that are abstracted in this MediFocus Guide includes:
- Correction of hyperinsulinemia
in oligoovulatory women with clomiphene-resistant polycystic ovary syndrome:
a review of therapeutic rationale and reproductive outcomes.
2000
- The importance of diagnosing the
polycystic ovary syndrome.
Annals of Internal Medicine. 2000
- The genetics of obesity. Lessons
for polycystic ovary syndrome.
Annals of the New York Academy of Sciences. 2000
- Hyperinsulinism and its interaction
with hyperandrogenism in polycystic ovary syndrome.
Obstetrical & Gynecological Survey. 2000
- Laparoscopic "drilling"
by diathermy or laser for ovulation induction in anovulatory polycystic
ovary syndrome.
Cochrane Database of Systematic Reviews [computer file]. 2000
- Pulsatile luteinising hormone releasing
hormone for ovulation induction in subfertility associated with polycystic
ovary syndrome.
Cochrane Database of Systematic Reviews [computer file]. 2000
- Ovulation induction with urinary
follicle stimulating hormone versus human menopausal gonadotropin for clomiphene-resistant
polycystic ovary syndrome.
Cochrane Database of Systematic Reviews [computer file]. 2000
- Gonadotrophin-releasing hormone
analogue as an adjunct to gonadotropin therapy for clomiphene-resistant
polycystic ovarian syndrome.
Cochrane Database of Systematic Reviews [computer file]. 2000
- Polycystic ovary syndrome: a risk
factor for cardiovascular disease?.
BJOG: an International Journal of Obstetrics & Gynaecology. 2000
- Genetic abnormalities in polycystic
ovary syndrome.
Annales d Endocrinologie. 1999
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treatment options, cutting-edge research, and new developments; excerpts
of important journal articles from the current medical literature focusing
on standard treatments and treatment options; a directory of leading authors
and medical institutions who specialize in the treatment of the condition;
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